Handling Di-calcium Phosphate properly is important for safety and the quality of the product. This product can irritate the eyes and with inhalation may cause mild chest discomfort. Values. Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. If they would like to be sure then they should conduct what is known as a disintegration test. Tricalcium phosphate (TCP), also known as bone phosphate of lime (BPL), E341, or tribasic calcium phosphate, is a calcium salt of phosphoric acid. We only recommend adding a maximum of 2% of this to the mix. pregnancy, upcoming surgery, etc. It has the chemical formula Ca3(PO4)2. Phosphorous and Calcium to a consumers diet will improve bodily functions in many ways. Di-calcium Phosphate is an ingredient in a range of different products. It is used in pharmaceutical or over-the-counter (e.g., multivitamin) products.… JavaScript seems to be disabled in your browser. Which excipient should I add if the product doesn't bind well? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Dicalcium phosphate is mainly used as a dietary supplement in prepared breakfast cereals, dog treats, enriched flour, and noodle products. Phosphate is a mineral commonly derived from rocks, however, occasionally from bones and whey (from cheese-making). LFA's Di-calcium Phosphate arrives as a crystalline powder. There is no evidence in the available information on calcium phopshate that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future. What is the shelf life? If the amount of MCC you would have to use would be too much or if you do not want to use MCC then you have 3 other options: Ask your supplier for a directly compressible or tabletable grade of your product. However, too much dicalcium phosphate, or dicalcium phosphate taken in conjunction … Overview of pharmaceutical excipients used in tablets and capsules. For the best experience on our site, be sure to turn on Javascript in your browser. This ensures each tablet will be the same. Select one or more newsletters to continue. Diluents are added to pharmaceutical tablets or capsules to make the product large enough for swallowing and handling, and more stable. Firmapress is an all in one mix of Microcrystalline Cellulose, Magnesium Stearate and Dicalcium Phosphate. As a dietary supplement, take 2,000 mg (rounded 1/2 tsp) once or twice daily, or as directed by your physician. Lactose - Binder, sweetener and bulking agent. Dicalcium Phosphate E341(i) is used as nutritional supplement and buffering agent in food such as in biscuits, milk powder, drinks, ice cream, biscuit, breakfast cereals, infant formula, in noodles and baked food. It is unlikely that you will be able to produce tablets without using any Excipients at all. Magnesium Stearate is a dry lubricant and helps again with the movement of ingredients through the machine but also helps with the ejection of the tablets from the machine. It can also help with powder flow issues and caking issues. Calcium phosphate is a widely used pharmaceutical excipient as binder and filler in solid oral dosage forms which include compressed tablets and hard gelatin capsules. Dicalcium Phosphate is a white, tasteless, microcrystalline powder that is frequently utilized in foods and beverages as a buffering agent, a dough modifier, an emulsifier, a leavening agent, a nutritional supplement, or a stabilizer. i.e. We comply with the HONcode standard for trustworthy health information -. HCaO4P. Do any of the excipients increase the speed of damage to tooling? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Before using Dicalcium Phosphate, inform your doctor about your current list of medications, over the counter products (e.g. Various calcium phosphates are used as diluents in the pharmaceutical industry. Good at binding tablets and making them bigger. You do not have to do this if you used an ultrasonic cleaner in the last step. Any known factors that can affect the rate, speed up or slow down the breakdown of a tablet? Di-calcium Phosphate is an effective flowing agent that will contribute nutrients to your formula. It can be added to many foods as a supplement to contribute to both a humans and animals well-being. Microcrystalline Cellulose - Binder, filling agent. Dicalcium Phosphate is a flowing agent and helps move ingredients through the machine before they are compressed. If your product or API is clumpy then you will need to add an anticaking agent. Titanium dioxide – a colourant used to make tablets and capsules bright white. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Take this medication by mouth with food. This can be used in any % the limiting factor is the size of the tablet. This assist powders in flowing smoothly through the machines. In cosmetics and personal care products, the Calcium Phosphate ingredients are used in the formulation of blushers, dentifrices, eye makeup, eyeliners, face powders, foundations, lipsticks, other makeup products and skin care products. Please note that Magnesium Sterate does not bind by itself. Enter your details to get the User manual, Spec Sheet and Video links for the Dicalcium Phosphate. Dicalcium phosphate is a calcium supplement commonly found in prepared breakfast cereals, in pharmaceuticals as an inert ingredient to bind tablets, and in toothpastes. Yes, all of the excipients are safe for human or animal consumption. Compressibility is the ease at which a powder forms in to a solid tablet. here are 6 steps that should be followed as a general rule of thumb when cleaning contact surfaces that have come into contact with powders: Dry Clean - First you need to remove as much of the dry powder as possible. Dicalcium phosphate powder has a chalky taste. The intolerance sheets can be found here: https://www.lfatabletpresses.com/product-data, How to Make Your Own Tablets - Free eBook. Dicalcium phosphate [CAS: 7757-93-9], (also known as calcium hydrogen phosphate, phosphoric acid), CAHPO 4, is used in the food industry in the fortification of various products. Magnesium stearate - Dry Lubricant. Yes, we have bulk pricing for all of our excipients and it can be found in this section. Di-calcium Phosphate comes in different mesh sizes. The coarser grades supplied here flow well and have excellent compressibility.Â. Dicalcium phosphate is used as a food additive, it is found in some toothpastes as a polishing agent and is a biomaterial. Dibasic calcium phosphate dihydrate (USP/NF), Calcium Hydrogen Phosphate Dihydrate (Ph.Eur.) We advise that you use our Firmapress ready mix as this works with 99% of products. Available for Android and iOS devices. Dicalcium Phosphate Dosage. Diluents are added to pharmaceutical tablets or capsules to make the product large enough for swallowing and handling, and more stable. If your product does not bind well then we would recommend using MCC. When handling, you should use protective eye gear, gloves and an inhalation mask. Dicalcium phosphate is a calcium supplement generally found in pharmaceuticals as an inert ingredient to bind tablets, in prepared breakfast cereals, and in toothpaste. 1). © 2020 LFA Machines Oxford LTD. All Rights Reserved. It is also known as dibasic calcium phosphate or calcium monohydrogen phosphate. It is also known as dibasic calcium phosphate or calcium monohydrogen phosphate. These products help the breakdown of tablets. – a coarse grade DI-CAFOS D 160 is the most widely used product for direct compression because of its very good both compaction and flow properties while a fine grade DI-CAFOS D 14 is very popular product used mainly in wet granulation processes. Yes, Dicalcium Phosphate, if used in high amounts, will cause more damage to tooling than just Firmapress or MCC. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Dicalcium phosphate supplements are available as pills, capsules and in complexes for bone support. It's used in the production of tablets and capsules as a "flowing agent". It is not an ingredient found in any natural food. Usual Adult Dose for Osteomalacia: 1 to 2 tablets orally once a day. It ensures that your ingredients will run through machinery with ease. It will be white or off-white, odourless and free-flowing. Spray dry your product. We offer Microcrystalline Cellulose, Magnesium Stearate, Dicalcium Phosphate and Firmapress in our range of excipients. Store - Finally store any of the parts in a cool dry place. Dicalcium Phosphate dinyatakan bertujuan untuk merawat tahap kalsium darah rendah, osteoporosis, osteomalacia / riket serta keadaan lain. It used as an anti-caking agent as it can absorb small amounts of moisture. At the moment LFA does not sell any supper disintegrants. It is also used as a tableting agent in some pharmaceutical preparations and it is used as a feed for poultry. Make sure that the vacuum you are using has a filter good enough to handle fine dust. It contributes to animal’s metabolism, and accelerates growth and development. Inorganic chemical compound with the formula CaHPO 4. We do not recommend that you add more than 1% to the mix as more than this can cause capping. You can do this using a hover/vacuum. There are two things at play here. If your product is sticky then you will need to add a dry lubricant to your mix. Dicalcium Phosphate (DCP) USE: Mixed with other ingredients in animal feeds, DCP is mainly designed for breeding purposes (cattle, poultry...).Used as the main source of Phosphorus and Calcium, DCP strenghens the skeleton and accelerates the animal’s growth. Take this medication by mouth with food. The utilituy of Dicalcium phosphate dihydrate (DCPD), a commonly used water insoluble pharmaceutical excipient, has been investigated for its use in formulating a controlled release matrix type tablet for highly water soluble drugs. Are all excipients safe for all ages to consume? Choose your local phone number or click "Email Us" to send us a message and for other ways to reach us. [2], [1] Dave RH. This should be with the appropriate grade oil or grease considering your use and greasing chart. We offer bulk in 500kg, 1 ton, 2 ton and 5 ton lots. Wet granulate your product. Chemical Formula. In Beverage. 2H 2 O. Accessed 03/24/2012, [2] FDA’s SCOGS database; calcium phosphate dibasic; SCOGS-Report Number: 32; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=58. 2H 2 O) is the most stable phase themodynamically when pH is 4.2 or lower (Fig. Additionally, it means that your final products will have consistent ingredients throughout. Learn whether this means taking calcium phosphate supplements can give you healthier bones.